Bleeding risk with systemic thrombolytic therapy for pulmonary embolism: scope of the problem
نویسندگان
چکیده
منابع مشابه
Pulmonary Embolism Thrombolytic Therapy of Pulmonary Embolism A Meta-Analysis
OBJECTIVES We sought to assess the efficacy and safety of thrombolytic therapy in patients with an acute pulmonary embolism (PE). BACKGROUND Thrombolytic therapy is approved for the treatment of acute PE; however, the safety and efficacy of this therapy remain debated. METHODS A meta-analysis of randomized, controlled trials comparing thrombolytic agents with intravenous heparin in patients wit...
متن کامل[Thrombolytic therapy of acute pulmonary embolism].
Thrombolytic therapy accelerates the dissolution of acute pulmonary embolism and is potentially lifesaving. The goal of this article is to offer a critical analysis of the use of thrombolytic therapy in this setting. Guidelines have been written and modified and new ones have been published over the past several years. Although an evidence base exists, unanswered questions remain. Despite the p...
متن کاملPulmonary embolism--the role of thrombolytic therapy in its management.
In massive pulmonary embolism where there may be evidence of right ventricular dysfunction and acute pulmonary hypertension, anticoagulation therapy alone may prove inadequate. In such situations use of thrombolytic agents produces an improvement in haemodynamics compared to anticoagulants alone, although studies to date have been too small to address the issue of mortality benefit. It would ap...
متن کاملSystemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis
AIM Thrombolytic therapy induces faster clot dissolution than anticoagulation in patients with acute pulmonary embolism (PE) but is associated with an increased risk of haemorrhage. We reviewed the risks and benefits of thrombolytic therapy in the management of patients with acute PE. METHODS AND RESULTS We systematically reviewed randomized controlled studies comparing systemic thrombolytic ...
متن کاملIs Thrombolytic Therapy Effective for Pulmonary Embolism? -- American Family Physician
www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 1097 160 patients with angiographically documented PE were divided into two groups, each of which received standard heparin or urokinase. Lung scans, pulmonary angiograms and measurements of right heart pressures and blood flow dynamics performed at 24 hours showed significant improvement only in the urokinase group. However, lung scans performed seven...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Therapeutic Advances in Drug Safety
سال: 2015
ISSN: 2042-0986,2042-0994
DOI: 10.1177/2042098615572333